Screening Platform: Compounds, Functional Genomics, and Therapeutics

The Screening Discovery Platform (SDP) provides expertise in the drug discovery pipeline for assay development and high-throughput screening. We have automated Screening Platforms in BSL2+ (Opera Phenix Plus, Operetta CLS, Ensight, Envision) / BSL3 (Operetta CLS, Nivo) to support research activities.

All types of assay models (phenotypic, target, 3D) can be run against our libraries for drug repositioning, new chemical entities, target ID, and MOA assessment.

  • Validating and formatting assays to 96/384/1536 well format to perform screening activities
  • Chemical library collection of 400K compounds identified as potential starting points for the development of novel therapeutics
  • Genomic platforms (siRNA and shRNA technology) to identify new targets and signaling pathways as well as uncover mechanism of actions
  • Advanced liquid handlers to support any workflow processes including Echo Acoustic Dispenser, Biomek, and Janus.

Development areas: High Throughput Screening, High Content Screening, Small Molecule, Drugs, Functional Genomics, Target ID & MOA, Ai-driven analysis.

Our objective is to create customized, cost-effective tool and instrument utilizing readily available technology to address scientific needs. Once you reach out to us, we will arrange a teleconference meeting to delve into the project. Subsequently, we will engage in an iterative interaction, progressing from the initial design concept to the actual creation of the tool or instrument. This comprehensive approach may span several months to ensure a successful and satisfying outcome

Thanks to its multidisciplinarity, this laboratory provides a platform for specialized analyzes such as genotyping of resistance to antivirals, genotyping of IL28B, search for mutations in Hereditary Hemochromatosis type 1 (HFE), deficiencies in Alpha anti -trypsin, etc.

L.i1000SR is a multiparametric immunology analyzer capable of performing up to 100 tests per hour.

It utilizes microparticle chemiluminescent immunoassay (CMIA) technology to determine the presence of antigens, antibodies, or analytes in the analyzed samples.

MALDI-ToF is a mass spectrometry technique used routinely for rapid identification of bacterial strains.

It can also be used to generate reference spectrum databases of bacteria, fungi, mosquitoes and other vectors.

The luminex is a device for multiplexing proteomic or genomic analyses. Applications: ELISA assays, sequence detection, gene expression, etc.

The ChemiDoc MP is an imaging detection instrument for the analysis of electrophoresis gels and Western blots. Applications include chemiluminescence, fluorescence, and colorimetry/densitometry.

Our expertise includes the folding of the synthesized proteins and the determination of disulfide bond patterns when present using proteomic tools (enzymatic digestion followed by mass spectrometry analysis). The secondary structure of the proteins can be studied using circular dichroism

Go@L is the genomic plateforme of the UAR (Unité d’Appui et de Recherche) PLBS (Plateformes Lilloises en Biologie & Santé) UMS2014 US41. This plateforme is composed of 2 laboratories, one team (GFS) at the CHRU and one team (TAG) at the Institute Pasteur de Lille. The plateforme is specialized in genomic and transcriptomic based on the use and development of molecular biology applications using high throughput sequencing technologies.
Our main applications are :
– Genomic : WGS, WES, amplicon-seq, Tn-seq, CGH-arrays.
– Transcriptomic : RNA-seq, sRNA-seq, bacterial RNA-seq, NGS-RACE, RNA-seq full-length, DGE, single-cell RNA-seq, spatial transcriptomic.
– Metagenomic : targeted bacterial 16S metagenomic

The Animal Experimentation and High Technology Platform (PLEHTA) is specialized in hosting and establishing rodent animal models under highly controlled containment conditions. The platform includes multiple animal facilities (SPF, SOPF, biosafety levels 2 and 3), allowing maximum flexibility for the wide variety of demands by research groups from different disciplines including infections, cardiovascular and neurodegenerative diseases, metabolism, oncology, pharmacology and toxicology.