Next Generation Sequencing Platform

Third generation ONT Sequencer.

MinIon – Genomic Surveillance Platform

Pathogens characterization: Sars-CoV-2, Rift and Mpox.

An Illumina’s Iseq100 will be available soon.

The CRB-IPM being vital for biomedical research and clinical research, its primary objective is the conservation of quality biological resources, in compliance with all applicable legal, regulatory and ethical provisions. The CRB-IPM offers services allowing you to deposit, preserve and characterize your biological samples. The CRB-IPM uses state-of-the-art equipment such as the Microflex Bruker MALDI-TOF (Matrix Assisted Laser Desorption Ionisation – Time of Flight) mass spectrometer and a flow cytometer (cell culture collections to come), as well as its skills in strain typing and bioinformatics to guarantee the identity and characteristics of the strains in the collection.

The CRB-IPM uses state-of-the-art equipment such as the Microflex Bruker MALDI-TOF (Matrix Assisted Laser Desorption Ionisation – Time of Flight) mass spectrometer and a flow cytometer (cell culture collections to come), as well as its skills in strain typing and bioinformatics to guarantee the identity and characteristics of the strains in the collection.

The Unit is in charge of:

  • Measuring the impact of malaria control measures and epidemiological changes on transmission and the reservoir.
  • Studying of Host-Parasite interactions during Plasmodium vivax infections – one of the parasites responsible for malaria in Madagascar.
  • the development of serological diagnostic tests that can be easily used in Basic Health Centers and allow rapid diagnosis of pathologies such as Leptospirosis and Cysticercosis/Neurocysticercosis.
  • Studying the prevalence of parasitoses associated with diarrhea and malnutrition in children in Madagascar.
  • Capacity building in immunology to improve the use and mastery of the main immunological techniques necessary for the development of research projects against infectious diseases.

The MAGPIX Luminex Technology is available at the Virology Laboratory

The LoopampTM MTBC assay (Eiken Chemical Company Ltd, Tokyo, Japan) is a rapid molecular diagnostic that uses the loop-mediated isothermal amplification (LAMP) technique for the detection of tuberculosis (TB). This assay is commonly known as TB-LAMP. In 2016, based on a systematic review and meta-analysis of data from 20 studies conducted in 17 countries, the World Health Organization (WHO) recommended the use of TB-LAMP as a replacement for sputum smear microscopy.

TB-LAMP’s minimal infrastructure requirements and simple instrumentation make it an attractive option for laboratories at the peripheral level in low-and middle-income countries, as well as for active case-finding activities that result in significant numbers of samples that can be batch tested using the HumaLoop T instrument (up to 70 samples per 8-hour shift). The price of $6.00 per sample when batching optimally means TB-LAMP is currently the only WHO-recommended rapid molecular diagnostic that meets the target price established by WHO for a replacement test for microscopy.

Illumina, Nanopore technologies are available.