Protein-Protein Interaction Validation in Living Cells

Our platform facilitates the exploration of protein-protein interactions (PPI) within living cells, utilizing a diverse range of high-throughput methods. We harness the power of the Bioluminescence Resonance Energy Transfer (BRET) technique for the precise quantification of proteins of interest, including, for example, pathogen/host protein pairs. What distinguishes our method is its capability to continuously monitor these interactions in real time within living cells for extended durations. This versatile approach supports a wide array of applications, including PPI validation, time-lapse PPI cell quantification, assessment of affinity in mutant PPI pairs, PPI competition studies, and screening for PPI modulators in drug discovery.