Fiocruz’s Network Technological Platforms.
The Bioassays for screening anti-tuberculosis drugs platform performs microbiological tests to detect activity of natural and synthetic compounds against the M. tuberculosis complex, non-tuberculosis mycobacteria and others bacterias, using the broth microdilution method with oxidation indicator (MTT), colony count (UFC), BACTEC MGIT 960 and early bactericidal activity. This platform also perform tests with resistent strains. In addition, cytotoxicity assays using the MTT method and bactericidal activity in macrophage are offered when a compound shows activity against the mycobacteria tested.
This platform is located in FIOCRUZ – Rio de Janeiro (INI).
Head of Platform: Maria Cristina da Silva Lourenco;
Technical Manager: Leonardo Bruno Paz Ferreira Barreto