This facility is part of the Institut Pasteur’s Center for Animal Resources and Research.

It produces mice harboring a human immune system (HIS mice) and provide expertise for the possible applications of this model.

HIS mice engrafted with human Hematopoietic stem cells (HSC) are advantageous in vivo models for long-term studies in the field of human immune cells biology, immune-oncology and infectious disease. They constitute a small animal model in which to analyze potency and safety of new drugs modulating the immune system.

The Institut Pasteur d’Algérie counts the following ressources:

• Bacterial ressources.
• Fungi and parasite ressources.
• Virus and cell-lines ressources.
• Production & breeding of laboratory animal lines.
• Insectarium: mosquito maintenance and insecticides testing.

The Animal Research Lab (ANL) is responsible for designing animal experiment models for various diseases and conducting in vivo experiments to investigate the efficacy of infectious disease vaccines and therapeutic candidates. ANL also conducts preclinical research on animal experiments to evaluate the practical use of the results obtained through basic and translational research at IPK. In particular, ANL establishes new drug candidate evaluation platforms and manages the welfare and housing of research animals.

The Animal Research Lab capabilities/assets includes:

• Establishing infectious disease animal models
• Generating animal models for human diseases utilizing state-of-the-art technologies, enabling research collaboration in the field of biomedical research
• Performing in vivo efficacy/toxicity studies
• Developing technologies for the quality control of the laboratory animals and generating genetically engineered mice (GEM)
• In total, over 550 m² (5,920 ft²) of dedicated animal space
  • Specific pathogen free (SPF) zone
  • Animal biosafety level-2, 3 laboratories
• Trained veterinary staff provide expertise in animal husbandry, transgenic mouse breeding colony maintenance and assistance with routine technical procedures
• Adhering to AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International) standards in order to demonstrate commitment to humane and responsible animal research and dedication to good science.

The Insectarium propose the following procedures:

• Mosquito breeding for insecticide sensitivity testing
• Mosquito vector competence
  Mosquito serological test

The building’s technological flagship is its level 3 biosafety laboratory designed to perform experimental infections of insects or vertebrates in order to study their role as vector and/or reservoir and to understand the interactions between hosts and pathogenic, particularly for arboviruses.

With a total surface area of 100 m2, composed of five rooms as well as its own laundry, the laboratory is notably equipped with several microbiological safety stations as well as all the prescribed and necessary equipment.

Fiocruz’s Network Technological Platforms.

Animal development, knockout, knock-in, transgenic, edited.

This platform is located in FIOCRUZ – Rio de Janeiro (ICTB).

Fiocruz’s Network Technological Platforms
Laboratory animals: cryopreservation of embryos and gametes.

This platform is located in FIOCRUZ – Rio de Janeiro (ICTB).

The production and research complex of Pasteur Institute of Iran was founded in 1988 on the Tehran Karaj Highway. It was established to meet the increasing population demand for products such as various solutions and vaccines and providing requirements for research like different laboratory animals

The aims of the Department of Animal Models for Biomedical Research (DAMBR) are the breeding, supply and use of laboratory animals for modeling human pathologies and for developing cutting-edge technologies in academic and research areas, for performing toxicological and preclinical studies in pharmaceutical industry, and for academic education. DAMBR collaborates with the groups and technological infrastructures of HPI and supports their research projects.

The Animal Experimentation and High Technology Platform (PLEHTA) is specialized in hosting and establishing rodent animal models under highly controlled containment conditions. The platform includes multiple animal facilities (SPF, SOPF, biosafety levels 2 and 3), allowing maximum flexibility for the wide variety of demands by research groups from different disciplines including infections, cardiovascular and neurodegenerative diseases, metabolism, oncology, pharmacology and toxicology.