The Medicinal Chemistry team focuses on the optimization of compounds which are identified as effective against target diseases through primary screening.
The areas of activity include:
- Advancing and accelerating the optimization on drug discovery program
- Developing novel chemical platform technology for innovative drug discovery (Establishment of PROTAC platform)
- Developing probe molecules for identifying target and understanding the in vivo mechanism of drug candidates
- Developing tool compounds for monitoring drug localization in either the cell or living animal
- Provide open analytical chemistry services, synthesis know-hows and molecular modeling analysis by giving access to IPK’s well-equipped infrastructure to support academia and pharmaceutical companies.
Official name in French: Laboratoire Sécurité Alimentaire Hygiène Environnement (LSAHE). The laboratory develops polluant and contaminants analysis. E.g. heavy metals.
This platform has suitable technologies with high precisions and high specificities including Enzyme-Linked Immunosorbent Assay (ELISA), and Enzyme-Linked Fluorescent Assay (ELFA/VIDAS), significantly proficient to detect antigens/ anti-bodies (as alternative/complementary to gold standard PCR technique), for diagnosing infectious diseases (viral, bacterial, parasitic), making differential diagnosis, and application in epidemiological surveillance.
The Unit is in charge of:
- Measuring the impact of malaria control measures and epidemiological changes on transmission and the reservoir.
- Studying of Host-Parasite interactions during Plasmodium vivax infections – one of the parasites responsible for malaria in Madagascar.
- the development of serological diagnostic tests that can be easily used in Basic Health Centers and allow rapid diagnosis of pathologies such as Leptospirosis and Cysticercosis/Neurocysticercosis.
- Studying the prevalence of parasitoses associated with diarrhea and malnutrition in children in Madagascar.
- Capacity building in immunology to improve the use and mastery of the main immunological techniques necessary for the development of research projects against infectious diseases.
The MAGPIX Luminex Technology is available at the Virology Laboratory
The LoopampTM MTBC assay (Eiken Chemical Company Ltd, Tokyo, Japan) is a rapid molecular diagnostic that uses the loop-mediated isothermal amplification (LAMP) technique for the detection of tuberculosis (TB). This assay is commonly known as TB-LAMP. In 2016, based on a systematic review and meta-analysis of data from 20 studies conducted in 17 countries, the World Health Organization (WHO) recommended the use of TB-LAMP as a replacement for sputum smear microscopy.
TB-LAMP’s minimal infrastructure requirements and simple instrumentation make it an attractive option for laboratories at the peripheral level in low-and middle-income countries, as well as for active case-finding activities that result in significant numbers of samples that can be batch tested using the HumaLoop T instrument (up to 70 samples per 8-hour shift). The price of $6.00 per sample when batching optimally means TB-LAMP is currently the only WHO-recommended rapid molecular diagnostic that meets the target price established by WHO for a replacement test for microscopy.
VBS provides a wide range of services to meet the needs of the university research community and healthcare, research, and biotechnology companies. Apart from the technical services it offers, VBS provides high-level training in bioimaging.
The objective of the Analytical Chemistry Laboratory Applied to Health (C2AS) is to support research projects in the field of human, environmental and animal health that require expertise in analytical chemistry. The laboratory develops targeted analytical methods for measuring molecules of interest in various biological, environmental and food matrices, and in particular environmental pollutants (pesticides, heavy metals, etc.). C2AS has an analytical platform containing LC-MS/MS, GC-MS/MS and ICP-MS mass spectrometers, which currently enable targeted analysis of molecules of interest.
It operates in the field of medicinal chemistry, particularly the development of multitasking organometallic therapeutics
L.i1000SR is a multiparametric immunology analyzer capable of performing up to 100 tests per hour.
It utilizes microparticle chemiluminescent immunoassay (CMIA) technology to determine the presence of antigens, antibodies, or analytes in the analyzed samples.